Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol).
Identifieur interne : 000F06 ( Main/Exploration ); précédent : 000F05; suivant : 000F07Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol).
Auteurs : Bram Rochwerg [Canada] ; Simon Oczkowski [Canada] ; Reed Alexander Siemieniuk [Canada] ; Kusum Menon [Canada] ; Wojciech Szczeklik [Canada] ; Shane English [Canada] ; Thomas Agoritsas [Canada] ; Emilie Belley-Cote [Canada] ; Frédérick D'Aragon [Canada] ; Waleed Alhazzani [Canada] ; Erick Duan [Canada] ; Kira Gossack-Keenan [Canada] ; Jon Sevransky [États-Unis] ; Per Vandvik [Canada] ; Bala Venkatesh [Australie] ; Gordon Guyatt [Australie] ; Djillali Annane [Canada]Source :
- BMJ open [ 2044-6055 ] ; 2017.
Abstract
Sepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising adjunctive intervention. Despite a large number of trials examining this research question, uncertainty persists regarding the effect of corticosteroids on survival in sepsis. Several large randomised controlled trials have been published recently prompting a re-evaluation of the available literature.
DOI: 10.1136/bmjopen-2017-016847
PubMed: 28667229
Affiliations:
- Australie, Canada, États-Unis
- Géorgie (États-Unis), Nouvelle-Galles du Sud, Ontario
- Hamilton (Ontario), Sydney
- Université McMaster, Université de Sydney
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xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Oczkowski, Simon" sort="Oczkowski, Simon" uniqKey="Oczkowski S" first="Simon" last="Oczkowski">Simon Oczkowski</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Siemieniuk, Reed Alexander" sort="Siemieniuk, Reed Alexander" uniqKey="Siemieniuk R" first="Reed Alexander" last="Siemieniuk">Reed Alexander Siemieniuk</name><affiliation wicri:level="4"><nlm:affiliation>Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Menon, Kusum" sort="Menon, Kusum" uniqKey="Menon K" first="Kusum" last="Menon">Kusum Menon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Szczeklik, Wojciech" sort="Szczeklik, Wojciech" uniqKey="Szczeklik W" first="Wojciech" last="Szczeklik">Wojciech Szczeklik</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="English, Shane" sort="English, Shane" uniqKey="English S" first="Shane" last="English">Shane English</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine (Critical Care), University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine (Critical Care), University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Agoritsas, Thomas" sort="Agoritsas, Thomas" uniqKey="Agoritsas T" first="Thomas" last="Agoritsas">Thomas Agoritsas</name><affiliation wicri:level="4"><nlm:affiliation>Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Belley Cote, Emilie" sort="Belley Cote, Emilie" uniqKey="Belley Cote E" first="Emilie" last="Belley-Cote">Emilie Belley-Cote</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="D Aragon, Frederick" sort="D Aragon, Frederick" uniqKey="D Aragon F" first="Frédérick" last="D'Aragon">Frédérick D'Aragon</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke et Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke et Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Alhazzani, Waleed" sort="Alhazzani, Waleed" uniqKey="Alhazzani W" first="Waleed" last="Alhazzani">Waleed Alhazzani</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Duan, Erick" sort="Duan, Erick" uniqKey="Duan E" first="Erick" last="Duan">Erick Duan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gossack Keenan, Kira" sort="Gossack Keenan, Kira" uniqKey="Gossack Keenan K" first="Kira" last="Gossack-Keenan">Kira Gossack-Keenan</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Sevransky, Jon" sort="Sevransky, Jon" uniqKey="Sevransky J" first="Jon" last="Sevransky">Jon Sevransky</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University, Atlanta, Georgia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Emory University, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Vandvik, Per" sort="Vandvik, Per" uniqKey="Vandvik P" first="Per" last="Vandvik">Per Vandvik</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Venkatesh, Bala" sort="Venkatesh, Bala" uniqKey="Venkatesh B" first="Bala" last="Venkatesh">Bala Venkatesh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, Wesley Hospital and Princess Alexandra Hospital, University of Queensland, St Lucia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Intensive Care, Wesley Hospital and Princess Alexandra Hospital, University of Queensland, St Lucia</wicri:regionArea><wicri:noRegion>St Lucia</wicri:noRegion></affiliation></author><author><name sortKey="Guyatt, Gordon" sort="Guyatt, Gordon" uniqKey="Guyatt G" first="Gordon" last="Guyatt">Gordon Guyatt</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">BMJ open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising adjunctive intervention. Despite a large number of trials examining this research question, uncertainty persists regarding the effect of corticosteroids on survival in sepsis. Several large randomised controlled trials have been published recently prompting a re-evaluation of the available literature.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li></region><settlement><li>Hamilton (Ontario)</li><li>Sydney</li></settlement><orgName><li>Université McMaster</li><li>Université de Sydney</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Rochwerg, Bram" sort="Rochwerg, Bram" uniqKey="Rochwerg B" first="Bram" last="Rochwerg">Bram Rochwerg</name></region><name sortKey="Agoritsas, Thomas" sort="Agoritsas, Thomas" uniqKey="Agoritsas T" first="Thomas" last="Agoritsas">Thomas Agoritsas</name><name sortKey="Alhazzani, Waleed" sort="Alhazzani, Waleed" uniqKey="Alhazzani W" first="Waleed" last="Alhazzani">Waleed Alhazzani</name><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><name sortKey="Belley Cote, Emilie" sort="Belley Cote, Emilie" uniqKey="Belley Cote E" first="Emilie" last="Belley-Cote">Emilie Belley-Cote</name><name sortKey="D Aragon, Frederick" sort="D Aragon, Frederick" uniqKey="D Aragon F" first="Frédérick" last="D'Aragon">Frédérick D'Aragon</name><name sortKey="Duan, Erick" sort="Duan, Erick" uniqKey="Duan E" first="Erick" last="Duan">Erick Duan</name><name sortKey="English, Shane" sort="English, Shane" uniqKey="English S" first="Shane" last="English">Shane English</name><name sortKey="Gossack Keenan, Kira" sort="Gossack Keenan, Kira" uniqKey="Gossack Keenan K" first="Kira" last="Gossack-Keenan">Kira Gossack-Keenan</name><name sortKey="Menon, Kusum" sort="Menon, Kusum" uniqKey="Menon K" first="Kusum" last="Menon">Kusum Menon</name><name sortKey="Oczkowski, Simon" sort="Oczkowski, Simon" uniqKey="Oczkowski S" first="Simon" last="Oczkowski">Simon Oczkowski</name><name sortKey="Siemieniuk, Reed Alexander" sort="Siemieniuk, Reed Alexander" uniqKey="Siemieniuk R" first="Reed Alexander" last="Siemieniuk">Reed Alexander Siemieniuk</name><name sortKey="Szczeklik, Wojciech" sort="Szczeklik, Wojciech" uniqKey="Szczeklik W" first="Wojciech" last="Szczeklik">Wojciech Szczeklik</name><name sortKey="Vandvik, Per" sort="Vandvik, Per" uniqKey="Vandvik P" first="Per" last="Vandvik">Per Vandvik</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Sevransky, Jon" sort="Sevransky, Jon" uniqKey="Sevransky J" first="Jon" last="Sevransky">Jon Sevransky</name></region></country><country name="Australie"><noRegion><name sortKey="Venkatesh, Bala" sort="Venkatesh, Bala" uniqKey="Venkatesh B" first="Bala" last="Venkatesh">Bala Venkatesh</name></noRegion><name sortKey="Guyatt, Gordon" sort="Guyatt, Gordon" uniqKey="Guyatt G" first="Gordon" last="Guyatt">Gordon Guyatt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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